Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.
نویسندگان
چکیده
We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.
منابع مشابه
Characterization of ertapenem-resistant Enterobacter cloacae in a Taiwanese university hospital.
The emergence of carbapenem resistance in Enterobacteriaceae has become a great concern. The aim of this study was to characterize ertapenem-resistant Enterobacter cloacae isolates from a Taiwanese university hospital. A total of 355 nonduplicated E. cloacae isolates collected in 2007 were analyzed by antimicrobial susceptibility testing with and without an inhibitor of efflux pumps and AmpC β-...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 8 شماره
صفحات -
تاریخ انتشار 2006